Mathematical modeling of proteome constraints within metabolism

Genome-scale metabolic models (GEMs) are widely used to predict phenotypes with the aid of constraint-based modeling. In order improve predictive power these models, there have been many efforts on imposing biological constraints, among which proteome constraints particular interest. Here we describe concept and review proteome-constrained GEMs, as well their advantages applications. addition, discuss a key issue in field, i.e., low coverage enzyme-specific turnover rates, subsequently provide few solutions solve it. We end discussion trade-off between model complexity capability.